Invitrogen™ VE-cadherin Monoclonal Antibody (BV9)

Description

MA1-198 VE-Cadherin antibody detects human VE-cadherin by western blot, immunofluorescence and flow cytometry. This monoclonal antibody recognizes the extracellular domain of the VE-cadherin protein which is highly expressed at intercellular junctions of vascular endothelial cells such as Huvec.

VE-cadherin is a member of the cadherin superfamily that is located in a six-cadherin cluster in a region on the long arm of chromosome 16 and is involved in loss of heterozygosity events in breast and prostate cancer. VE-cadherin protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, VE-cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but the full length sequence of VE-cadherin has not been determined.