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Invitrogen™ ZO-1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marque: Invitrogen™ 402200
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Description
40-2200 was used successfully in the immunofluorescence analysis of Zo-1 in MDCK cells.
ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
Spécification
| ZO-1 | |
| Polyclonal | |
| Unconjugated | |
| TJP1 | |
| DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 21872, 292994, 403752, 7082 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry | |
| 0.25 mg/mL | |
| PBS with 0.1% sodium azide; pH 7.4 | |
| O97758, P39447, Q07157 | |
| TJP1 | |
| Synthetic peptide in the middle region of the ZO-1 protein. | |
| 100 μg | |
| Primary | |
| Canine, Human, Mouse, Rat | |
| Antibody | |
| IgG |
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