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Caspase-3/CPP32 Mouse anti-Mouse, Unlabeled, Clone: 46, BD

Mouse Monoclonal Antibody

Marque:  BD Biosciences 611048

Informations supplémentaires : Poids : 0.01000kg

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Code produit. 15855779

  • 308.94€ / 1 kit
Expédition estimée: 23-02-2023
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Description

Description

Apoptosis, a selective process of genetically programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptotic cells are characterized by loss of cell volume, plasma membrane blebbing, nuclear condensation, chromatin aggregation, and endonucleocytic degradation of DNA into nucleosomal fragments. Caspase-3 (CPP32, Yama, apopain) is a member of the family of cysteine proteases which includes interleukin-1beta-converting enzyme (ICE) and C. elegans protein, Ced-3. An apoptotic signal such as granzyme B of cytotoxic T-cells (CTLs) or ICE-like proteases induces the intracellular cleavage of Caspase-3 from the inactive proform (32kDa) to the active form which consists of the p20, p17, and p12 subunits. The active form of Caspase-3 cleaves several other apoptotic proteins including proteins such as DNA fragmentation factor (DFF). Apoptosis can be inhibited by coexpression of Bcl-2 as well as inhibitors of Caspase-3 or other members of the family of cysteine proteases. This antibody recognizes the mouse 32kDa pro-Caspase-3 and the p17 cleaved form of Caspase 3 in T cell lymphocytes treated with camptothecin.

Immunofluorescence, Western Blotting

Spécification

Spécification

Caspase-3/CPP32
Monoclonal
250μg/mL
CPP32
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Western Blot
46
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Mouse CPP32 aa. 25-145
50 μg
Cell Biology
Mouse
IgG1
Vidéos
FDS
Documents

Documents

Certificats
Promotions

Promotions

For Research Use Only.