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CD27 Mouse anti-Human, Brilliant Violet 650, Clone: L128, BD

Mouse Monoclonal Antibody

Marque:  BD Biosciences 563228

Informations supplémentaires : Poids : 0.01000kg

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Code produit. 15852619

  • 678.30€ / 1 pièce
Expédition estimée: 27-02-2023
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Description

Description

The L128 monoclonal antibody specifically binds to human CD27. CD27 is a 55-kDa disulfide-linked dimer that is a member of the nerve growth factor (NGF) super family. This family also includes CD40, rat OX40, tumor necrosis factor (TNF) receptors and CD95 (Fas). With its ligand CD70, CD27 acts in a co-stimulatory fashion on T lymphocytes. Present on most peripheral blood T lymphocytes and medullary thymocytes, the CD27 antigen is upregulated upon activation with the release of a soluble form, 28 to 32 kDa. It is also detected on a subpopulation of approximately 33% of circulating B lymphocytes. Following exposure to antigens, CD45RA+ T lymphocytes respond by upregulating the CD27 antigen. After maximal stimulation, the CD27 antigen cannot be re-expressed on long-term cultures or on CD45RA-CD27+ T lymphocytes. The CD4+CD27- population is contained within the memory CD45RO+ subset that proliferates after exposure to allergens. Two subpopulations of B lymphocytes bearing the CD27 antigen secrete IgM ( δ +) and IgG ( δ -).

Spécification

Spécification

CD27
Monoclonal
Brilliant Violet 650
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Human Activated Peripheral Blood Cells
100 Tests
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Flow Cytometry
L128
TNFRSF7; Tumor necrosis factor receptor superfamily, member 7; Tp55; S152
Mouse
Affinity Purified
RUO
Human
IgG1
Vidéos
FDS
Documents

Documents

Certificats
Promotions

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For Research Use Only.