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CD4 Rat anti-Mouse, PE, Clone: RM4-5, BD

Rat Monoclonal Antibody

Marque:  BD Biosciences 553049

Informations supplémentaires : Poids : 0.01000kg

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Code produit. 15856958

  • 272.46€ / 1 pièce
Expédition estimée: 21-02-2023
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Description

Description

The RM4-5 clone has been reported to react with the CD4 (L3T4) differentiation antigen expressed on most thymocytes, subpopulations of mature T lymphocytes (i.e., MHC class II-restricted T cells, including most T helper cells and immunosuppressive regulatory T cells), and a subset of NK-T cells. CD4 has also been reported to be detected on pluripotent hematopoietic stem cells, bone marrow myeloid and B-lymphocyte precursors, intrathymic lymphoid precursors, and a subset of splenic dendritic cells. CD4 has been reported to be expressed on the plasma membrane of mouse egg cells and is involved in adhesion of the egg to MHC class II-bearing sperm. CD4 is an antigen coreceptor on the T-cell surface which interacts with MHC class II molecules on antigen-presenting cells. It participates in T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase lck. Purified RM4-5 mAb has been reported to block the binding of FITC-conjugated anti-mouse CD4 clones GK1.5 and H129.19, but not the RM4-4 clone. This antibody is routinely tested by flow cytometric analysis and is compatible with intracellular staining protocols using the BD Cytofix/Cytoperm™ Kit (Cat. No. 554714). Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Host Species: Rat
Clone: RM4-5
Isotype: IgG2a κ
Species Reactivity: Mouse
Immunogen: Mouse Thymocytes (BALB/c)

Flow Cytometry, Intracellular Staining

Spécification

Spécification

CD4
Monoclonal
0.2mg/mL
Cd4; CD4 antigen; L3T4; Ly-4; T-cell surface antigen T4/Leu-3
Rat
Affinity Purified
RUO
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Flow Cytometry
RM4-5
PE
Aqueous buffered solution containing ≤0.09% sodium azide.
Mouse Thymocytes (BALB/c)
0.2 mg
Immunology
Mouse
IgG2a κ
Vidéos
FDS
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For Research Use Only.