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Cyclin B Mouse, Unlabeled, Clone: 18, BD
Mouse Monoclonal Antibody
218.28€ - 315.65€
Spécification
| Antigène | Cyclin B |
|---|---|
| Clone | 18 |
| Concentration | 250μg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
| Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
|---|---|---|---|---|---|---|---|---|---|
| Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
|
15845339
|
BD Biosciences
610219 |
50 μg |
 219.00€ 218.28€ / 1 kit Économisez 0.72€ 0.33% de réduction |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | |||||
|
15855339
|
BD Biosciences
610220 |
150 μg |
316.00€ 315.65€ / 1 kit Économisez 0.35€ 0.11% de réduction |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | |||||
Description
The B-type cyclins serve as subunits of the major mitotic protein kinase in many different organisms. In mammals, Cyclin B is a subunit for the cdc2 (Cdk1) protein kinase and is synthesized during late S and G2 phases. Cyclin B associates with inactive cdc2 and facilitates phosphorylation of cdc2 at Thr-14 and Tyr-15. This phosphorylation maintains the inactive state until the end of G2. The inactive Cyclin B-cdc2 complex continues to accumulate in the cytoplasm until the CDC25 phosphatase dephosphorylates Thr-14 and Tyr-15, rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when Cyclin B becomes degraded. This degradation process appears to be ubiquitin-dependent and is necessary for the cell to exit mitosis. Also, the conserved domain in B-type cyclins, known as the P box, is required for CDC25 activation.
This antibody is routinely tested by western blot analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.
Spécification
| Cyclin B | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG1 | |
| Affinity Purified |
| 18 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Human, Rat | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.
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