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Flotillin-1 Mouse, Unlabeled, Clone: 18, BD

Mouse Monoclonal Antibody

Marque:  BD Biosciences 610821

Informations supplémentaires : Poids : 0.01000kg

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Code produit. 15845659

  • 665.76€ / 1 kit
Expédition estimée: 20-02-2023
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Description

Description

Caveolae are specialized membrane invaginations of 50-100 nm present in all cells, but abundant in endothelium, muscle cells, and adipocytes. These plasma membrane microdomains function in transcytosis of macromolecules, and are the sites of potocytosis, where small molecules are concentrated and transferred inside the cells by glycosylphosphatidylinositol (GPI)-linked receptors. Caveolin, a 22kDa protein and a well known marker for these plasma membrane microdomains, plays a structural role in these specializations. Flotillin-1 was isolated from the Triton X-100 insoluble buoyant fraction, characteristic of caveolae. Although the mRNA expression of both Flotillin-1 and Caveolin
is very similar, Caveolin is undetectable in brain, while Flotillin-1 is very abundant. Flotillin-1 is a close homolog of the Epidermal Surface Antigen (ESA/Flotillin-2), which also colocalizes in the caveolae. Thus, Flotillin-1 and its relative ESA/Flotillin-2 are now incorporated into the expanding list of proteins co-localized at the caveolae which includes PKCα, Ras, Rap Src-like kinases, Gαβγ,and GPI-linked receptors.

Immunofluorescence, Immunoprecipitation, Western Blotting

Spécification

Spécification

Flotillin-1
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Mouse Flotillin aa. 312-428
150 μg
Cell Biology
Rat, Mouse, Human, Chicken
IgG1
Western Blot
18
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
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For Research Use Only.