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HAX-1 Mouse, Unlabeled, Clone: 52, BD

Mouse Monoclonal Antibody

Marque:  BD Biosciences 610824

Informations supplémentaires : Poids : 0.01000kg

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Code produit. 15875659

  • 274.38€ / 1 kit
Date d’expédition estimée: 29-12-2021

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Description

Description

Cell-cell interactions in the immune system, mediated by membrane-bound antigen receptors, trigger a cascade of signaling mechanisms collectively known as the T-cell response. Upon antigen binding, cellular tyrosine kinases are activated resulting in the phosphorylation of HS1 or Lck-binding protein 1 (LckBP1), which is involved in thymic negative selection. HS1 is one of the earliest intracellular proteins to be tyrosine phosphorylated in response to antigen-receptor cross-linking in T cells. HAX-1 (HS1-associated protein X-1) is a 35kDa protein found associated with HS1 by co-immunoprecipitation assays and the two-hybrid system. HAX-1 is ubiquitously expressed and localized in the mitochondria, endoplasmic reticulum, and the nuclear envelope. The HS1-HAX-1 complex may be critical for signal transduction pathways initiated by antigen presentation to T cells.

Immunofluorescence, Immunoprecipitation, Western Blotting

Spécification

Spécification

HAX-1
52
Unconjugated
Affinity Purified
Human HAX-1 aa. 10-148
50μg
Cell Biology
Primary
Human, Murine, Rat
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Mouse
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Vidéos
FDS
Documents
Certificats
Promotions

Promotions

For Research Use Only.