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LAR Mouse, Unlabeled, Clone: 7, BD

Mouse Monoclonal Antibody

Marque:  BD Biosciences 610350

Informations supplémentaires : Poids : 0.01000kg

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Code produit. 15875409

  • 425.22€ / 1 kit
Expédition estimée: 20-02-2023
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Description

Description

The Leukocyte common Antigen-Related (LAR) receptor protein tyrosine phosphatase (RPTP) is one of approximately 20 known, distinct transmembrane RPTPs. LAR consists of an extracellular region with three Ig-like and eight fibronectin type III-like (FNIII) domains and a cytoplasmic region containing two tyrosine phosphatase domains typical of RPTPs. The Ig and FNIII domains of LAR show some sequence similarity to domains in the neural cell adhesion molecule N-CAM, a neural surface glycoprotein which mediates cell adhesion and neurite outgrowth. Studies suggest that LAR regulates neurite outgrowth and pathfinding during neural development. N-CAM and other cell adhesion molecules that affect neurite outgrowth, such as L1, TAG-1, and fasciculin II, lack intrinsic kinase or phosphatase activity. Thus, LAR is part of a distinct class of proteins with both cell adhesion and tyrosine phosphatase functions. LAR transcripts are alternatively spliced and that splicing is regulated during development. It is postulated that the various spliced forms of LAR each have specialized functions in the nervous system and play a role in neural development and regeneration.

Spécification

Spécification

LAR
Monoclonal
250μg/mL
Leukocyte common Antigen-Related
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Western Blot
7
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
and ≤0.09% sodium azide., glycerol, Aqueous buffered solution containing BSA
50 μg
Cell Biology
Rat, Mouse, Human
IgG2a
Vidéos
FDS
Documents

Documents

Certificats
Promotions

Promotions

For Research Use Only.