missing translation for 'onlineSavingsMsg'
Learn More

NK-1.1 Mouse anti-Mouse, PE-Cy7, Clone: PK136, BD

Mouse Monoclonal Antibody

Marque:  BD Biosciences 562062

Informations supplémentaires : Poids : 0.00840kg

 Afficher plus de versions de ce produit

Code produit. 15851609

  • 175.56€ / 1 pièce
Expédition estimée: 01-03-2023
pour voir le stock disponible 

Veuillez vous pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant!


Description

Description

In the mouse, at least three members of the Klrb (Killer cell lectin-like ; formerly NKR-P1) gene family have been identified (Klrb1a/NKR-P1A, Klrb1b/NKR-P1B, and Klrb1c/NKR-P1C); but in the human gene family, a single homologue has been designated KLRB1, NKR-P1A, or CD161. The KLRB1/NKR-P1 family of proteins are type-II-transmembrane C-type lectin receptors. KLRB1C/NKR-P1C activates NK-cell cytotoxicity, while KLRB1B/NKR-P1B functions as an inhibitory receptor. KLRB1B/NKR-P1B protein has intracellular Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM), while KLRB1C/NKR-P1C lacks ITIM and activates via association with Fc Receptor γchain. Strikingly, KLRB1B/NKR-P1B and KLRB1C/NKR-P1C share 96% amino acid sequence identity in their extracellular C-type lectin domains. The PK136 antibody reacts with the NK-1.1 surface antigen (CD161c) encoded by the Klrb1c/NKR-P1C gene expressed on natural killer (NK) cells in selected strains of mice (eg, C57BL, FVB/N, NZB, but not A, AKR, BALB/c, CBA/J, C3H, C57BR, C58, DBA/1, DBA/2, NOD, SJL, 129) and the CD161b antigen encoded by the Klrb1b/NKR-P1B gene expressed only on Swiss NIH and SJL mice, but not on C57BL/6. Expression of KLRB1C/NKR-P1C protein is correlated with the ability to lyse tumor cells in vitro and to mediate rejection of bone marrow allografts. The NK-1.1 marker is useful in defining NK cells; however, the antigen is also expressed on a rare, specialized population of T lymphocytes (NK-T cells) and some cultured monocytes. Plate-bound PK136 mAb, in combination with low concentrations of IL-2, induces proliferation of a subset of NK cells.

Spécification

Spécification

NK-1.1
Monoclonal
0.2mg/mL
Klrb1b, CD161b, Nkrp1b; Klrb1c, CD161c, NK1.1, Nkrp1c
Mouse
Affinity Purified
RUO
Mouse
IgG2a κ
Flow Cytometry
PK136
PE-Cyanine7
Aqueous buffered solution containing ≤0.09% sodium azide.
Mouse NK-1+ Spleen and Bone Marrow Cells
25 μg
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Vidéos
FDS
Documents

Documents

Certificats
Promotions

Promotions

For Research Use Only.