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PKCε Mouse, Unlabeled, Clone: 21, BD

Mouse Monoclonal Antibody

Marque:  BD Biosciences 610086

Informations supplémentaires : Poids : 0.01000kg

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Code produit. 15855249

  • 605.34€ / 1 kit
Expédition estimée: 20-02-2023
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Description

Description

The Protein Kinase C (PKC) family of homologous serine/threonine protein kinases is involved in a number of processes such as growth, differentiation, and cytokine secretion. At least eleven isozymes have been described. These proteins are products of multiple genes and alternative splicing. PKC consists of a single polypeptide chain containing four conserved regions (C) and five variable regions (V). The N-terminal half containing C1, C2, V1, and V2 constitutes the regulatory domain and interacts with PKC activators Ca2), phospholipid, diacylglycerol, or phorbol ester. However, the novel PKC (nPKC) subfamily members (δ, η, η, and θ isoforms) and the atypical PKC (aPKC)
subfamily members (ζ , ι , and λ isoforms) are Ca(2+) independent and lack the C2 domain. The PKC pathway represents a major signal transduction system that is activated following ligand-stimulation of transmembrane receptors by hormones, neurotransmitters and growth factors. Expression of the 90kDa PKCα is induced by interferon-α. Generally, PKCα is expressed at very low levels in normal murine tissues, except brain. Overexpression of PKCα leads to increased growth rates and higher cell densities in monolayer cultures. A high level of expression is seen in several hematopoietic cell lines and tumors. This suggests a possible role for PKCα in tumorigenesis.

Host Species: Mouse
Clone: 21
Isotype: IgG2a
Species Reactivity: Rat
Immunogen: Human PKCε aa. 1-175
Formula Weight [Chemical]: 90kDa

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Spécification

Spécification

PKCε
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Human PKCε aa. 1-175
150 μg
Cell Biology
Rat, Mouse, Human, Chicken, Canine
IgG2a
Western Blot
21
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
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For Research Use Only.