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Rb2 Mouse, Unlabeled, Clone: 10, BD

Mouse Monoclonal Antibody

Marque:  BD Biosciences 610262

Informations supplémentaires : Poids : 0.01000kg

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Code produit. 15845369

  • 647.52€ / 1 kit
Expédition estimée: 21-02-2023
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Description

Description

The pRb2 protein shows a high degree of identity with pRb and the related p107 protein. Both pRb and p107 bind to the adenovirus E1A, SV40 large T antigen, and papillomavirus E7 viral proteins. This binding initiates the release of transcription factors which are required for the expression of cell cycle-regulated genes. pRb, pRb2, and p107 interact with a conserved motif in these three viral proteins. In the E1A protein, this area is known as transforming domain 2, which is required for growth activation. The E1A-binding domain in pRb and p107 is a conserved motif known as the “pocket region” which consists of conserved A and B regions separated by non-conserved spacers of different sizes in pRb and p107. It is the pocket regions of pRb and p107 that associate with the E2F transcription factor. pRb2 also contains the conserved pocket region suggesting that it has functional similarities to pRb and p107.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Spécification

Spécification

Rb2
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
150 μg
Cell Biology
Rat, Mouse, Human, Drosophila, Chicken
IgG2a
Western Blot
10
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Vidéos
FDS
Documents

Documents

Certificats
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For Research Use Only.