missing translation for 'onlineSavingsMsg'
Learn More

RONα Mouse, Unlabeled, Clone: 29, BD

Mouse Monoclonal Antibody

Marque:  BD Biosciences 610744

Informations supplémentaires : Poids : 0.01000kg

 Afficher plus de versions de ce produit

Code produit. 15855619

  • 308.94€ / 1 kit
Expédition estimée: 22-02-2023
pour voir le stock disponible 

Veuillez vous pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant!


Description

Description

RON (Recepteur d′ Origine Nantaise) is a tyrosine kinase receptor for MSP (Macrophage Stimulating Protein) that belongs to the hepatocyte growth factor receptor family. RON is synthesized as a single chain glycosylated polypeptide of 1400 amino acids that is cleaved upon maturation into a 150kDa β-subunit with the kinase activity and a 40kDa α-chain. Both chains are linked by disulfide bonds and the proper arrangement of the α and β heterodimer is necessary for biological activity of RON. MSP induces the tyrosine kinase activity of RON, triggering a cascade of intracellular signaling that leads to DNA synthesis. However, RON activation in mouse erythroleukemia cells results in apoptosis. The replacement of autophosphorylation sites Y1330 and Y1337 abolishes both the mitogenic and apoptotic effects of MSP. Therefore, autophosphorylation at Y1330 and Y1337 is required for RON's biological activity. PLCγ, Shc, Grb2, p61, and p65 associate with RON. Although widely expressed, RON is particularly abundant in epithelial tissues, lung, brain, adrenal glands, gastrointestinal tract, kidney and testis.

Immunofluorescence, Immunoprecipitation, Western Blotting

Spécification

Spécification

RONα
Monoclonal
250μg/mL
Recepteur d'Origine Nantaise
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Western Blot
29
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Human RONα aa. 40-224
50 μg
Cell Biology
Rat, Mouse, Human, Frog, Canine
IgG2b
Vidéos
FDS
Documents

Documents

Certificats
Promotions

Promotions

For Research Use Only.