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APEX1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 10203-1-AP-150UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16836433

  • 325.38€ / 150µL
Expédition estimée: 04-10-2022
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Description

Description

10203-1-AP is a rabbit polyclonal antibody raised against full length APE1 of human origin.

Mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is a multifunctional, bipartite enzyme that plays an important role in numerous, cellular functions. APE is responsible for repairing abasic sites in DNA and in regulating the redox state of other proteins that play roles in oxidative signaling, transcription factor regulation (Fos, Jun, NF-kB, Myb, HIF-1 alpha, CREB, Pax), cell cycle control (p53), and apoptosis. The most common form of DNA damage is the creation of abasic sites which are brought about through spontaneous loss or oxidative DNA damage, through chemically initiated hydrolysis (chemotherapy), ionizing radiation, UV irradiation, oxidizing agents, and removal of modified bases by DNA glycosylases. APE is differentially expressed during development and in different tissues. This protein has diverse subcellular localization patterns which support the possibility of its interaction with numerous, other cellular proteins in addition to DNA repair within the nucleus. Regulation of APE by phosphorylation is mediated, at least in part, by casein kinase II. Increases in APE message and protein levels are observed upon the reintroduction of oxygen to hypoxic cells, and in some maligt tissue relative to normal tissue. Decreases in APE expression have been associated with the induction of cellular apoptosis.
Spécification

Spécification

APEX1
Polyclonal
Unconjugated
APEX1
AP endonuclease 1, APE, APE1, APE1,APEX1, APEN, APEX, APEX nuclease, APEX1, APX, HAP1, Protein REF 1, REF1
Rabbit
Antigen Affinity Chromatography
RUO
11792, 328, 79116
-20°C
Liquid
Western Blot, Immunoprecipitation, Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry
0.3 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P27695, P28352, P43138
APEX1
APEX1 Fusion Protein Ag0251
150 μL
Primary
Rat, Mouse, Human
Antibody
IgG
Vidéos
FDS
Documents
Certificats
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