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ASK1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 28201-1-AP-150UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16836045

  • 325.38€ / 150µL
Expédition estimée: 06-10-2022
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Description

Description

Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was recently identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activated two different subgroups of MAPKK, MKK4 and MKK6, which in turn activated c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death, and a catalytically inactive form of ASK1 inhibited TNF-a-induced apoptosis. ASK1 is expressed in variety of human and mouse tissues.
Spécification

Spécification

ASK1
Polyclonal
Unconjugated
MAP3K5
ASK 1, ASK1, MAP3K5, MAPK/ERK kinase kinase 5, MAPKKK5, MEK kinase 5, MEKK 5, MEKK5
Rabbit
Antigen Affinity Chromatography
RUO
26408, 4217
-20°C
Liquid
Western Blot, Immunohistochemistry (Paraffin)
0.47 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
O35099, Q99683
Map3k5
ASK1 Fusion Protein Ag28092
150 μL
Primary
Mouse, Human
Antibody
IgG
Vidéos
FDS
Documents
Certificats
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