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CD19 Mouse, anti-Human, R718, Clone: SJ25C1, BD Horizon™

Mouse Monoclonal Antibody

Marque:  BD Biosciences 566946

Informations supplémentaires : Poids : 0.00060kg

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Code produit. 17257734

  • 508.00€ / 100 tests
Expédition estimée: 13-12-2022
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Description

Description

The SJ25C1 monoclonal antibody specifically binds to CD19, a B lymphocyte-lineage differentiation antigen. CD19, a 90-kDa transmembrance glycoprotein, is a member of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell through the mature B-cell stages. Terminally differentiated plasma cells do not express CD19. On the surface of mature B cells, the CD19 molecule associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to promote cellular activation. Studies with CD19-deficient mice have suggested that the level of CD19 expression affects the generation and maturation of B cells in the bone marrow and periphery. B-1 lineage B cells, also known as CD5+ B cells, are drastically reduced or absent in CD19-deficient mice. Increased levels of CD19 expression correlate with increased frequencies of peritonal and splenic B-1 cells and reduced numbers of conventional B lymphocytes in the periphery. CD19 participates in B-lymphocyte development, B-cell activation, maturation of memory B cells and regulation of tolerance. CD19 has also been detected on peritoneal mast cells, co-localized with CD21/CD35, and it is proposed to play a role in complement-mediated mast-cell activation.

Spécification

Spécification

CD19
Monoclonal
R718
100 Tests
Primary
Refrigerate Upon Arrival
Flow Cytometry
SJ25C1
Mouse
RUO
Human
Liquid
Vidéos
FDS
Documents
Certificats
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