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CD27 Mouse anti-Human, Clone: 1C1G3, Proteintech

Mouse Monoclonal Antibody

Marque:  Proteintech 66308-1-IG-150UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16838065

  • 325.38€ / 150µL
Expédition estimée: 10-10-2022
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Description

Description

CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily that includes CD40 and CD30. The TNF superfamily members are known for the regulation of cell proliferation and death. In contrast to the expression of other TNFR/TNF family members, expression of CD27 and its ligand CD70 is predomitly confined to lymphocytes. High expression levels of CD27 appear to be dependent on proper ligation of antigen receptors. CD70 expression requires additional co-stimulatory and/or pro-inflammatory signals. CD27 is expressed as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells and a subpopulation of B cells. Activation of T cells via TCR-CD3 complex results in upregulation of CD27 expression on the plasma membrane as well as in the release of its soluble 28-32 kDa form, sCD27, detected in the plasma, urine or spinal fluid. Soluble CD27 is an important prognostic marker of acute and chronic B cell maligcies. RgpA, a cystein proteinase, although activating T cells through the protease-activated receptors (PARs), degradates CD27 and counteracts T cell activation mediated by CD27 and its ligand CD70. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. Diseases associated with CD27 dysfunction include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Syndrome.
Spécification

Spécification

CD27
Monoclonal
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P26842
CD27
CD27 Fusion Protein Ag24537
150 μL
Primary
Human
Antibody
IgG1
Western Blot, Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry
1C1G3
Unconjugated
CD27
CD27, CD27 antigen, CD27 molecule, CD27L receptor, S152, T cell activation antigen CD27, T14, TNFRSF7, Tp55
Mouse
Protein A
RUO
939
-20°C
Liquid
Vidéos
FDS
Documents
Certificats
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