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CD279 Mouse anti-Human, FITC, Clone: MIH4, BD
Mouse Monoclonal Antibody
201.00€ - 460.00€
Spécification
Antigène | CD279 |
---|---|
Clone | MIH4 |
Concentration | 0.5mg/mL |
Applications | Flow Cytometry |
Classification | Monoclonal |
Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
---|---|---|---|---|---|---|---|---|---|
Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
15830709
|
BD Biosciences
561035 |
25 μg |
201.00€
1 pièce |
Expédition estimée: 05-06-2024 Connectez-vous pour voir le stock disponible |
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15879078
|
BD Biosciences
557860 |
0.1 mg |
460.00€
1 pièce |
Expédition estimée: 29-05-2024 Connectez-vous pour voir le stock disponible |
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Description
The MIH4 monoclonal antibody specifically binds to the program death 1 (PD-1) receptor CD279, a member of the Ig superfamily. CD279 is an immunoregulatory receptor expressed on activated T cells, B cells and myeloid cells. Mice deficient in CD279 show a breakdown of peripheral tolerance and manifest multiple autoimmune symptoms. It contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region. PD-L1 and PD-L2 are ligands of CD279 and are members of the B7 gene family. Interaction of CD279:PD-Ligands results in inhibition of T cell proliferation and cytokine secretion. Reports suggest that the B7/CTLA-4 pathway functions primarily to attenuate, limit, and/or terminate naοve T-cell activation in secondary lymphoid organs. The PD-ligand:CD279 pathway, on the other hand, may primarily attenuate, limit, and/or terminate T-, B-, and myeloid cell activation/effector function at sites of inflammation in the periphery.
Spécification
CD279 | |
0.5mg/mL | |
Monoclonal | |
Mouse | |
Human | |
Human PD-1 Transfected Cell Line | |
Primary | |
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
MIH4 | |
Flow Cytometry | |
FITC | |
RUO | |
Aqueous buffered solution containing ≤0.09% sodium azide. | |
IgG1 κ | |
Affinity Purified | |
PD-1; hPD-1; PD1; PDCD1; Programmed cell death 1; SLEB2 |
For Research Use Only.