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CD3 Rabbit anti-Human, Porcine, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 17617-1-AP-150UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16827554

  • 325.38€ / 150µL
Expédition estimée: 27-09-2022
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Description

Description

This anti-CD3 is a polyclonal antibody directed against the epsilon chain of human CD3 molecule.

The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.
Spécification

Spécification

CD3
Polyclonal
Unconjugated
CD3E
CD3, CD3 epsilon, CD3E, CD3-epsilon, T3E, TCRE
Rabbit
Antigen Affinity Chromatography
RUO
397455, 916
-20°C
Liquid
Western Blot, Immunoprecipitation, Immunohistochemistry (Paraffin), Flow Cytometry
0.23 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P07766, Q7YRN2
CD3E
CD3 Fusion Protein Ag11797
150 μL
Primary
Porcine, Human
Antibody
IgG
Vidéos
FDS
Documents
Certificats
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