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CD42b Rabbit anti-Human, Porcine, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 12860-1-AP-20UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16830804

  • 121.38€ / 20µL
Expédition estimée: 28-09-2022
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Description

Description

CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. CD42b expression and activation seems to be regulated by VEGF and PDGF. CD42b composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis. Further, CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. Several polymorphisms and mutations have been described in the CD42b, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.
Spécification

Spécification

CD42b
Polyclonal
Unconjugated
GP1BA
BSS, CD42b, CD42b alpha, GP1B, GP1BA
Rabbit
Antigen Affinity Chromatography
RUO
100515052, 2811
-20°C
Liquid
Western Blot, Immunohistochemistry (Paraffin)
0.33 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P07359
GP1BA
CD42b Fusion Protein Ag3893
20 μL
Primary
Porcine, Human
Antibody
IgG
Vidéos
FDS
Documents
Certificats
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