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CD73 Mouse anti-Human, Brilliant Ultraviolet 737, Clone: AD2, BD Horizon™

Mouse Monoclonal Antibody

Marque:  BD Biosciences 612813

Informations supplémentaires : Poids : 0.00020kg

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Code produit. 17267904

  • 340.00€ / 25 tests
Expédition estimée: 19-12-2022
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Description

Description

The AD2 monoclonal antibody specifically binds to ecto-5’-nucleotidase, a 70 kDa, glycosyl phosphatidylinositol (GPI)-anchored glycoprotein. CD73 is expressed on subsets of T and B lymphocytes, follicular dendritic cells, epithelial cells, endothelial cells and mesenchymal stem cells. Its expression on lymphocytes increases during T and B cell development. CD73 has enzymatic activity and catalyzes the dephosphorylation of adenosine monophosphate (AMP) converting it to adenosine. It has been suggested that CD73 can mediate costimulatory signals in T cell activation and adhesion of lymphocytes to endothelium.

The antibody was conjugated to BD Horizon BUV737 which is part of the BD Horizon Brilliant™ Ultraviolet family of dyes. This dye is a tandem fluorochrome of BD Horizon BUV395 with an Ex Max of 348-nm and an acceptor dye with an Em Max at 737-nm. BD Horizon Brilliant BUV737 can be excited by the ultraviolet laser (355 nm) and detected with a 740/35 filter. Due to the excitation of the acceptor dye by other laser lines, there may be significant spillover into channels detecting Alexa Fluor™ 700-like dyes (eg, 712/20-nm filter).

Spécification

Spécification

CD73
Monoclonal
Brilliant Ultraviolet 737
Mouse
Affinity Purified
RUO
Human
IgG1 κ
Flow Cytometry
AD2
Aqueous buffered solution containing ≤0.09% sodium azide.
Pre-B leukemia cell line
25 Tests
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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