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CRACR2A Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 15206-1-AP-20UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16834294

  • 121.38€ / 20µL
Expédition estimée: 30-09-2022
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Description

Description

This antibody recognizes both of CRACR2A-c and CRACR2A-a.

CRACR2A is a Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. CRACR2A acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. Further, CRACR2A regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, CRACR2A dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
Spécification

Spécification

CRACR2A
Polyclonal
Unconjugated
CRACR2A
CRAC channel regulator 2A, CRACR2A, EFCAB4B
Rabbit
Antigen Affinity Chromatography
RUO
84766
-20°C
Liquid
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Immunofluorescence, Western Blot
0.4 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q9BSW2
CRACR2A
CRACR2A Fusion Protein Ag7358
20 μL
Primary
Human
Antibody
IgG
Vidéos
FDS
Documents
Certificats
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