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Cyclin B1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 55004-1-AP-20UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16836435

  • 121.38€ / 20µL
Expédition estimée: 04-10-2022
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Description

Description

The antibody is specific to CCNB1. The observed 55-60 kDa band in western blotting maybe due to phosphorylation.

Cyclins bind to and regulate the activity of the Cyclin dependent protein kinases (CDKs). Cyclin B1 or CCNB1 is a regulatory protein involved in mitosis. It is essential for the control of the cell cycle at the G2/M transition. Cyclin B1 complexes with p34 (cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predomitly during G2/M phase. Cyclin B1 is not ubiquitinated during G2/M phase, resulting in its steady accumulation during G2 phase, followed by abrupt APC dependent destruction at the end of mitosis. Destruction of Cyclin B1 is required for cell cycle progression. Cyclin B1 is overexpressed in various cancers, including breast, prostate, and non-small cell lung cancer.
Spécification

Spécification

Cyclin B1
Polyclonal
Unconjugated
CCNB1
CCNB, CCNB1, cyclin B1, G2/mitotic specific cyclin B1
Rabbit
Antigen Affinity Chromatography
RUO
268697, 891
-20°C
Liquid
Western Blot, Immunoprecipitation
0.35 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P14635, P24860
CCNB1
Peptide
20 μL
Primary
Mouse, Human
Antibody
IgG
Vidéos
FDS
Documents
Certificats
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