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Cyclin D2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 10934-1-AP-150UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16837653

  • 325.38€ / 150µL
Expédition estimée: 06-10-2022
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Description

Description

Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex By similarity.
Spécification

Spécification

Cyclin D2
Polyclonal
Unconjugated
CCND2
CCND2, cyclin D2, G1/S-specific cyclin-D2
Rabbit
Antigen Affinity Chromatography
RUO
12444, 894
-20°C
Liquid
Western Blot
0.3 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P30279, P30280
CCND2
Cyclin D2 Fusion Protein Ag1377
150 μL
Primary
Mouse, Human
Antibody
IgG
Vidéos
FDS
Documents
Certificats
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