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DDX58 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 20566-1-AP-20UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16830125

  • 121.38€ / 20µL
Expédition estimée: 28-09-2022
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Description

Description

The antibody is specific to DDX58.

Retinoic acid-inducible gene I, RIG-I is a pattern recognition receptor (PRR) involved in the recognition of viral dsRNA. Along with MDA5, RIG-I detects viral dsRNA and activates the innate immune response. Both MDA5 and RIG-I are RNA helicases and they perform overlapping as well as distinct roles. RIG-I is activated by dsRNAs without a 5′-triphosphate end and short dsRNAs, whereas MDA5 is activated by long dsRNAs. Once activated, both proteins signal through IPS-1 activating transcription factors NF-kappaB and IRF-3 (1) and ultimately activating apoptosis, cytokine signaling, and inflammation. RIG-I is essential for signaling by influenza A, influenza B, human respiratory syncytial virus (3), paromyxoviruses, Japanese encephalitis virus, and West Nile virus. MicroRNA-146a has been implicated in feedback inhibition of RIG-I-dependant antiviral response by negatively regulating RIG-I targets TRAF6, IRAK1, and IRAK2. Recent evidence has implicated RIG-I in the detection of cytosolic DNA through RNA polymerase III activity.
Spécification

Spécification

DDX58
Polyclonal
Unconjugated
DDX58
DDX58, DEAD box protein 58, RIG 1, RIG I, RIG-I
Rabbit
Antigen Affinity Chromatography
RUO
230073, 23586
-20°C
Liquid
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
0.51 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O95786, Q6Q899
Ddx58
Peptide
20 μL
Primary
Human, Mouse
Antibody
IgG
Vidéos
FDS
Documents
Certificats
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