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DOK6 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 14108-1-AP-150UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16802604

  • 329.85€ / 150µL

Date d’expédition estimée: 22-06-2021

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Description

Description

DOK-6 (docking protein 6), is a novel member of the Dok-4/5 subclass of the p62 Dok family of intracellular adaptor molecules. Dok-6 is highly expressed in the developing central nervous system and is co-expressed with Ret in several locations, including sympathetic, sensory, and parasympathetic ganglia, as well as in the ureteric buds of the developing kidneys. Pull-down assays using the Dok-6 phosphotyrosine binding (PTB) domain and GDNF-activated Ret indicate that Dok-6 binds to the phosphorylated Ret Tyr(1062) residue. Moreover, ligand activation of Ret resulted in phosphorylation of tyrosine residue(s) located within the unique C terminus of Dok-6 predomitly through a Src-dependent mechanism, indicating that Dok-6 is a substrate of the Ret-Src signaling pathway. (Crowder RJ, Enomoto H, Yang M, Johnson EM Jr, Milbrandt J. Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth. J Biol Chem. 2004 Oct 1;279(40):42072-81. Epub 2004 Jul 30. It is also known as DOK6, HsT3226, MGC20785 or IRS. 0.
Spécification

Spécification

DOK6
0.2 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q2MHE5, Q6PKX4
docking protein 6, DOK5L, DOK6, HsT3226
Rabbit
IgG
150 μL
-20°C
Primary
220164, 498898, 623279
Western Blot
Unconjugated
DOK6
Liquid
Dok6
DOK6 Fusion Protein Ag5254
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Vidéos
FDS
Documents
Certificats