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Factor XII Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 12551-1-AP-20UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16830314

  • 121.38€ / 20µL
Expédition estimée: 06-10-2022
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Description

Description

This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.
Spécification

Spécification

Factor XII
Polyclonal
Unconjugated
F12
Coagulation factor XII, F12, Factor XII, HAE3, HAEX, HAF, Hageman factor
Rabbit
Antigen Affinity Chromatography
RUO
2161, 306761, 58992
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot
0.2 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
D3ZTE0, P00748, Q80YC5
F12
Factor XII Fusion Protein Ag3401
20 μL
Primary
Human, Mouse, Rat
Antibody
IgG
Vidéos
FDS
Documents
Certificats
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