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FoxP3 Mouse, anti-Human, R718, Clone: 259D/C7, BD Horizon™

Mouse Monoclonal Antibody

341.00€ - 525.00€

Spécification

Antigène FoxP3
Clone 259D/C7
Applications Flow Cytometry
Classification Monoclonal
Conjugué R718
Consulter d'autres spécifications

Produits 2
Code produit Marque Quantité Prix Quantité et disponibilité  
Code produit Marque Quantité Prix Quantité et disponibilité  
17257724
Afficher les documents Détails de la promotion
BD Biosciences
566936
25 Tests
341.00€
25 tests
Voir les produits de remplacement
Économisez jusqu'à 
»
Expédition estimée: 22-04-2024
pour voir le stock disponible 
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17247724
Afficher les documents Détails de la promotion
BD Biosciences
566935
100 Tests
525.00€
100 tests
Voir les produits de remplacement
Économisez jusqu'à 
»
Expédition estimée: 16-04-2024
pour voir le stock disponible 
Veuillez vous pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant!
Description

Description

The 259D/C7 monoclonal antibody specifically recognizes human Forkhead box protein P3 (FoxP3) that is also known as Scurfin. FoxP3 is encoded by FOXP3 (Forkhead box P3), likewise known as IPEX (Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked) and JM2, that belongs to the forkhead/winged-helix family of transcriptional regulators. FoxP3 is expressed in CD4+ regulatory T cells (Treg) and represents a specific marker for these cells. Flow cytometric analyses have shown that FoxP3 is expressed by the majority of CD4+CD25+high T cells in peripheral blood while less than half of the CD4+CD25+intermediate cell population are FoxP3 positive. Approximately 5-10% of peripheral CD4+ cells are CD4+CD25+ T regulatory cells. T regulatory cells are thought to play a critical role in the regulation of T cell-mediated immunity and to protect against autoimmunity by suppressing the proliferation and cytokine production of other T cells. In support of this hypothesis, it has been found that Foxp3 is mutated in Scurfy (sf) mice that have defective T cell tolerance leading to an X-linked lymphoproliferative disease. The 259D/C7 antibody recognizes all currently-identified isoforms of human FoxP3 and is crossreactive with FoxP3 from Cynomolgus, Rhesus and Baboon primates.

Spécification

Spécification

FoxP3
Flow Cytometry
R718
Mouse
Human
Refrigerate Upon Arrival
259D/C7
Monoclonal
Liquid
RUO
Primary
Vidéos
FDS
Documents

Documents

Product Certifications