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IL31 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 22859-1-AP-150UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16832115

  • 325.38€ / 150µL
Expédition estimée: 30-09-2022
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Description

Description

Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.
Spécification

Spécification

IL31
Polyclonal
Unconjugated
IL31
IL 31, IL31, interleukin 31
Rabbit
Antigen Affinity Chromatography
RUO
386653, 76399
-20°C
Liquid
Western Blot, Immunohistochemistry (Paraffin)
0.26 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q6EAL8, Q6EBC2
IL31
IL31 Fusion Protein Ag18848
150 μL
Primary
Mouse, Human
Antibody
IgG
Vidéos
FDS
Documents
Certificats
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