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IRAK1 Mouse anti-Human, Clone: 1H10A7, Proteintech

Mouse Monoclonal Antibody

Marque:  Proteintech 66653-1-IG-20UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16828735

  • 121.38€ / 20µL
Expédition estimée: 10-10-2022
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Description

Description

Interleukin-1 receptor-associated kinase 1 (IRAK1) is a serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. IRAK is associated with Toll-like receptor (TLR) and IL-1R signaling pathways. It is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. IRAK′s association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and subsequent degradation. IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus. This results in the transcriptional activiation of type I IFN genes, which drive the cell in an antiviral state.
Spécification

Spécification

IRAK1
Monoclonal
1 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P51617
IRAK1
IRAK1 Fusion Protein Ag0728
20 μL
Primary
Human
Antibody
IgG2a
Western Blot, Immunohistochemistry (Paraffin)
1H10A7
Unconjugated
IRAK1
IRAK, IRAK 1, IRAK1, pelle
Mouse
Protein A
RUO
3654
-20°C
Liquid
Vidéos
FDS
Documents
Certificats
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