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KIAA1598 Rabbit anti-Human, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 24383-1-AP-150UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16832855

  • 325.38€ / 150µL
Expédition estimée: 30-09-2022
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Description

Description

SHTN1 is a protein coding gene involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or ′clutch engagement′ within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.
Spécification

Spécification

KIAA1598
Polyclonal
Unconjugated
SHTN1
KIAA1598, shootin 1
Rabbit
Antigen Affinity Chromatography
RUO
292139, 57698
-20°C
Liquid
Western Blot
0.17 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
A0MZ66, A0MZ67
SHTN1
KIAA1598 Fusion Protein Ag18294
150 μL
Primary
Rat, Human
Antibody
IgG
Vidéos
FDS
Documents
Certificats
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