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KIR2DS4 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 21152-1-AP-20UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16830765

  • 121.38€ / 20µL
Expédition estimée: 30-09-2022
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Description

Description

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
Spécification

Spécification

KIR2DS4
Polyclonal
Unconjugated
KIR2DS4
CD158I, KIR1D, KIR2DS4, KIR412, KKA3, MHC class I NK cell receptor, NKAT 8, NKAT8, p58 NK receptor CL 39/CL 17
Rabbit
Antigen Affinity Chromatography
RUO
3809
-20°C
Liquid
Immunocytochemistry, Immunofluorescence, Western Blot
0.53 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P43632
KIR2DS4
KIR2DS4 Fusion Protein Ag15711
20 μL
Primary
Human
Antibody
IgG
Vidéos
FDS
Documents
Certificats
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