missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Epredia™ Lab Vision™ SREBP-1 (Sterol Regulatory Element Binding Protein-1) Ab-1 Mouse Monoclonal Antibody, 200μg/mL, BSA and azide
Epredia™ SREBP-1 (Sterol Regulatory Element Binding Protein-1) Ab-1, Mouse Monoclonal Antibody provides accurate, reproducible results.
Marque: Epredia™ MS-1207-PABX
Les retours ne sont pas autorisés pour ce produit.
Afficher la politique du retour.
Description
SREBP-1 and -2 are transcription factors which participate in the control of cholesterol homeostasis. SREBPs proteins, which are attached to the endoplasmic reticulum and nuclear envelope, are proteolytically cleaved and thus activated in response to conditions of low cellular sterol. Upon activation of SREBP-1 or -2, an ∽480-500 amino acid, N-terminal cleavage fragment of these proteins enters the nucleus and activates transcription of enzymes and other proteins required for cholesterol synthesis. SCA (SREBP-cleavage activity) and caspase-3 proteases cleave SREBPs. SREBP proteins containing point mutations at caspase-3 cleavage sites (Asp460 in SREBP-1 and Asp468 in SREBP-2) do not become cleaved following induction of apoptosis, suggesting that SREBPs may play some role in apoptotic processes.Host Species: Mouse
Clone: 2A4
Isotype: IgG1/κ
Species Reactivity: Human and Hamster. Others not known.
Epitope: aa 301-407
Immunogen: Recombinant protein encoding N-terminal amino acids 301-407 (the bHLH/leucine zipper domain) of human SREBP-1
Molecular Weight: 125kDa (precursor) and 60-70kDa (cleaved)
Positive Control: HeLa and IMR5 cells
Cellular Localization: Cytoplasmic and nuclear
Recommended for:
- Western Blotting
- Immunoprecipitation (Not verified)
Note:
USA: RUO; Int'l: RUO
Spécification
| SREBP-1 (Sterol Regulatory Element Binding Protein-1) Ab-1 | |
| Monoclonal | |
| 1mg/mL | |
| Mouse | |
| 200 μL | |
| Transcription Regulation | |
| Hamster, Human | |
| IgG2a κ |
| Immunoprecipitation, Western Blot | |
| 2A4 | |
| Unconjugated | |
| Recombinant protein encoding N-terminal amino acids 301-407 (the bHLH/leucine zipper domain) of human SREBP-1 | |
| RUO | |
| Primary | |
| Concentrated |
Correction du contenu d'un produit
Veuillez fournir vos retours sur le contenu du produit en remplissant le formulaire ci-dessous.
Nom du produit
Vous avez repéré une opportunité d'amélioration ?Partager une correction de contenu