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LCK Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

140.00€ - 399.00€

Spécification

Antigène LCK
Concentration 0.51 mg/mL
Applications Western Blot
Classification Polyclonal
Conjugué Unconjugated
Consulter d'autres spécifications

Produits 2
Code produit Marque Quantité Prix Quantité et disponibilité  
Code produit Marque Quantité Prix Quantité et disponibilité  
16802975
Afficher les documents Détails de la promotion
Proteintech
24497-1-AP-20UL
20 μL
140.00€
20µL
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Expédition estimée: 15-04-2024
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16892965
Afficher les documents Détails de la promotion
Proteintech
24497-1-AP-150UL
150 μL
399.00€
150µL
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Économisez jusqu'à 
»
Expédition estimée: 15-04-2024
pour voir le stock disponible 
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Description

Description

LCK is a member of the Src-family tyrosine kinase, which are essential for signaling through the T-cell receptor (TCR) complex. Upon TCR triggering, LCK phosphorylates the ITAM motives in its zeta subunits establishing binding sites for the SH2 domains of the tyrosine kinase ZAP70, which is also phosphorylated by LCK and activated to generate subsequent signaling platforms by phosphorylation of adaptor LAT. The majority of LCK is localized to the plasma membrane, however, there is also a significant fraction associated with the Golgi apparatus which may contribute to Raf activation under conditions of weak stimulation through the TCR. LCK contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. LCK is also involved in the regulation of apoptosis induced by various stimuli, but not by the death receptors. Diseases associated with LCK include Immunodeficiency 22 and CD45 deficiency. Alternatively splice variants of the LCK gene encoding different isoforms of the protein have been found.
Spécification

Spécification

LCK
Western Blot
Unconjugated
Rabbit
Mouse, Human
P06239, P06240
16818, 3932
LCK Fusion Protein Ag21475
Primary
-20°C
LCK
0.51 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
LCK, LSK, p56 LCK, p56lck, pp58lck, Protein YT16, Proto oncogene Lck, Tyrosine protein kinase Lck, YT16
LCK
IgG
Antigen Affinity Chromatography
Antibody
Vidéos
FDS
Documents

Documents

Product Certifications