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MAVS/VISA Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 14341-1-AP-20UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16832934

  • 121.38€ / 20µL
Expédition estimée: 30-09-2022
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Description

Description

Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKK-a, IKK-b and IKK-iota kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.
Spécification

Spécification

MAVS/VISA
Polyclonal
Unconjugated
MAVS
CARDIF, IPS 1, IPS1, KIAA1271, MAVS, VISA
Rabbit
Antigen Affinity Chromatography
RUO
57506
-20°C
Liquid
Immunohistochemistry (Paraffin), Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
0.19 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q7Z434
MAVS
MAVS; VISA Fusion Protein Ag5655
20 μL
Primary
Human
Antibody
IgG
Vidéos
FDS
Documents
Certificats
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