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Phospho-TDP43 (Ser409, Ser410) Mouse anti-Human, Mouse, Rat, Clone: 1A2C1, Proteintech

Mouse Monoclonal Antibody

Marque:  Proteintech 66318-1-IG-20UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16828085

  • 121.38€ / 20µL
Expédition estimée: 10-10-2022
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Description

Description

66318-1-Ig is a phospho-dependent monoclonal antibody specifically recognizing phospho-TDP43 (409/410). It does not react with native TDP-43.

Various biochemical, physiological and behavioural processes display circadian rhythms controlled by an internal biological clock. The central "gears" driving this clock appear to be composed of an autoregulatory transcription/posttranslation-based feedback loop. Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases. In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function. Mammalian CRY1 and CRY2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM. They seem to act as light-independent components of the circadian clock and likely regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors. Mutant mice not expressing the Cry1 or Cry2 protein display accelerated and delayed periodicity of locomotor activity, respectively. It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases. A critical balance between Cry1 and Cry2 is required for proper clock function; in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock.
Spécification

Spécification

Phospho-TDP43 (Ser409, Ser410)
Monoclonal
1.5 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q13148, Q921F2
Tardbp
Peptide
20 μL
Primary
Rat, Mouse, Human
Antibody
IgG1
Western Blot
1A2C1
Unconjugated
TARDBP
ALS10, phospho(409/410)-TDP43, TAR DNA binding protein, TAR DNA binding protein 43, TARDBP, TDP 43, TDP43
Mouse
Protein G
RUO
230908, 23435, 298648
-20°C
Liquid
Vidéos
FDS
Documents
Certificats
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