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PSMB6 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

140.00€ - 399.00€

Spécification

Antigène PSMB6
Concentration 0.23 mg/mL
Applications Immunofluorescence, Western Blot, Immunocytochemistry, Immunohistochemistry (Paraffin)
Classification Polyclonal
Conjugué Unconjugated
Consulter d'autres spécifications

Produits 2
Code produit Marque Quantité Prix Quantité et disponibilité  
Code produit Marque Quantité Prix Quantité et disponibilité  
16898923
Afficher les documents Détails de la promotion
Proteintech
11684-2-AP-20UL
20 μL
140.00€
20µL
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Économisez jusqu'à 
»
Expédition estimée: 12-04-2024
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16888923
Afficher les documents Détails de la promotion
Proteintech
11684-2-AP-150UL
150 μL
399.00€
150µL
Voir les produits de remplacement
Économisez jusqu'à 
»
Expédition estimée: 12-04-2024
pour voir le stock disponible 
Veuillez vous pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant!
Description

Description

Proteolytic degradation is critical to the maintece of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signaling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Other proteins are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (∽31), barrel-shaped molecular machine with an apparent molecular weight of ∽2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. The PA28/11S REG Activator protein complex functions as a proteolytic activator. This complex, consisting of alpha, beta, and gamma subunits, enhances the activity of the 20S proteolytic core. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis (CF transmembrane regulator), Angelmane′s syndrome (E6-AP), and Liddle syndrome (endothelial sodium channels).
Spécification

Spécification

PSMB6
Immunofluorescence, Western Blot, Immunocytochemistry, Immunohistochemistry (Paraffin)
Unconjugated
Rabbit
Human, Mouse, Rat
P28072, P28073, Q60692
19175, 29666, 5694
PSMB6 Fusion Protein Ag2296
Primary
-20°C
PSMB6
0.23 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
20S proteasome, DELTA, LMPY, Macropain delta chain, Proteasome delta chain, Proteasome subunit beta type 6, Proteasome subunit Y, PSMB6, Y
Psmb6
IgG
Antigen Affinity Chromatography
Antibody
Vidéos
FDS
Documents

Documents

Product Certifications