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RIPK2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 15366-1-AP-20UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16834524

  • 121.38€ / 20µL
Expédition estimée: 29-09-2022
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Description

Description

Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes ′Lys-63′-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces ′Lys-63′-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.
Spécification

Spécification

RIPK2
Polyclonal
Unconjugated
RIPK2
CARD3, CARDIAK, CCK, GIG30, Receptor interacting protein 2, RICK, RIP 2, RIP2, RIPK2
Rabbit
Antigen Affinity Chromatography
RUO
192656, 362491, 8767
-20°C
Liquid
Western Blot
0.13 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O43353, P58801
Ripk2
RIPK2 Fusion Protein Ag0909
20 μL
Primary
Mouse, Human, Rat
Antibody
IgG
Vidéos
FDS
Documents
Certificats
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