RNPC3 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Beschreibung

U11/U12 snRNP 65K, also known as RBM40 (RNA-binding protein 40), RNPC3 (RNA-binding region-containing protein 3) or RNP, is a 517 amino acid nuclear protein that plays a role in pre-mRNA U12-dependent splicing by the minor spliceosome, ultimately leading to the removal of U12-type introns. Expressed at highest levels in kidney and pancreas, U11/U12 snRNP 65K is also weakly detected in placenta, heart, brain, lung, liver, thymus, colon, ovary, testis, prostate, spleen and small intestine. The gene encoding U11/U12 snRNP 65K maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson′s disease, Gaucher disease, schizophrenia and Usher syndrome.