missing translation for 'onlineSavingsMsg'
Learn More
Learn More
SHARPIN Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marque: Proteintech 14626-1-AP-20UL
Les retours ne sont pas autorisés pour ce produit.
Afficher la politique du retour.
Description
Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.Spécification
SHARPIN | |
Polyclonal | |
Unconjugated | |
SHARPIN | |
hSIPL1, SHARPIN, SIPL1 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
106025, 81858, 81859 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot, Immunoprecipitation | |
0.33 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
Q91WA6, Q9EQL9, Q9H0F6 | |
SHARPIN | |
SHARPIN Fusion Protein Ag6201 | |
20 μL | |
Primary | |
Rat, Human, Mouse | |
Antibody | |
IgG |