missing translation for 'onlineSavingsMsg'
Learn More

SHARPIN Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 14626-1-AP-20UL

Informations supplémentaires : Poids : 0.00010kg

 Afficher plus de versions de ce produit

Code produit. 16803364

  • 140.00€ / 20µL
Expédition estimée: 24-05-2024
pour voir le stock disponible 

Veuillez vous pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant!


Description

Description

Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.
Spécification

Spécification

SHARPIN
Polyclonal
Unconjugated
SHARPIN
hSIPL1, SHARPIN, SIPL1
Rabbit
Antigen Affinity Chromatography
RUO
106025, 81858, 81859
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunoprecipitation
0.33 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q91WA6, Q9EQL9, Q9H0F6
SHARPIN
SHARPIN Fusion Protein Ag6201
20 μL
Primary
Rat, Human, Mouse
Antibody
IgG
Suggestions de produits

Suggestions de produits

Vidéos
FDS
Documents

Documents

Certificats
Promotions

Promotions