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SHARPIN Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 14626-1-AP-20UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16803364

  • 112.71€ / 20µL

Expédition estimée
04-03-2021

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Description

Description

Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.
Spécification

Spécification

SHARPIN
0.33 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q91WA6, Q9EQL9, Q9H0F6
hSIPL1, SHARPIN, SIPL1
Rabbit
IgG
20 μL
-20°C
Primary
106025, 81858, 81859
Immunohistochemistry (Paraffin), Western Blot, Immunoprecipitation
Unconjugated
SHARPIN
Liquid
SHARPIN
SHARPIN Fusion Protein Ag6201
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Rat, Human, Mouse
Vidéos
FDS
Documents