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SHARPIN Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
140.00€ - 399.00€
Spécification
Antigène | SHARPIN |
---|---|
Concentration | 0.33 mg/mL |
Applications | Immunohistochemistry (Paraffin), Western Blot, Immunoprecipitation |
Classification | Polyclonal |
Conjugué | Unconjugated |
Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
---|---|---|---|---|---|---|---|---|---|
Code produit | Marque | Quantité | Prix | Quantité et disponibilité | |||||
16803364
|
Proteintech
14626-1-AP-20UL |
20 μL |
140.00€
20µL |
Expédition estimée: 12-06-2024 Connectez-vous pour voir le stock disponible |
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16893354
|
Proteintech
14626-1-AP-150UL |
150 μL |
399.00€
150µL |
Expédition estimée: 12-06-2024 Connectez-vous pour voir le stock disponible |
Veuillez vous connecter pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant! | ||||
Description
Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.Spécification
SHARPIN | |
Immunohistochemistry (Paraffin), Western Blot, Immunoprecipitation | |
Unconjugated | |
Rabbit | |
Rat, Human, Mouse | |
Q91WA6, Q9EQL9, Q9H0F6 | |
106025, 81858, 81859 | |
SHARPIN Fusion Protein Ag6201 | |
Primary | |
-20°C | |
SHARPIN |
0.33 mg/mL | |
Polyclonal | |
Liquid | |
RUO | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
hSIPL1, SHARPIN, SIPL1 | |
SHARPIN | |
IgG | |
Antigen Affinity Chromatography | |
Antibody |