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Arginase I Mouse, Unlabeled, Clone: 19, BD
Mouse Monoclonal Antibody
Marque: BD Biosciences 610708
Informations supplémentaires : Poids : 0.01000kg
Description
Arginase converts arginine into urea plus ornithine, the final step in urea synthesis. Two different isoforms (I&II) have been isolated with approximately 60% homology at the nucleotide level. While type II is present in many tissues, Arginase I is expressed exclusively in liver. In cultured macrophages, as well as in vivo, Arginase I is induced with nitric oxide synthase (NOS) and the arginase I transactivator C/EBPβ in response to lipopolysaccharide. This response occurs in a dose and time-dependent manner. While the mRNA for NOS appears as early as 2h after treatment, mRNA levels for arginase I peak after twelve hours of lipopolysaccharide treatment. Since the synthesis of nitric oxide by NOS requires arginine, the delayed induction of arginase I may be necessary for the regulation of NOS activity.
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Spécification
| Arginase I | |
| Monoclonal | |
| 250μg/mL | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| Human Arginase I aa. 53-207 | |
| 50 μg | |
| Cell Biology | |
| Drosophila, Mouse, Rat | |
| IgG1 |
| Western Blot | |
| 19 | |
| Unconjugated | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.