missing translation for 'onlineSavingsMsg'
Learn More

Hsp75/TRAP1 Mouse, Unlabeled, Clone: 42, BD

Mouse Monoclonal Antibody

Marque:  BD Biosciences 612344

Informations supplémentaires : Poids : 0.01000kg

 Afficher plus de versions de ce produit

Code produit. 15866169

  • 313.50€ / 1 pièce
Expédition estimée: 01-03-2023
pour voir le stock disponible 

Veuillez vous pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant!


Description

Description

The hsp90 family of molecular chaperones is involved in a number of signal transduction pathways, including cell division, protein folding and transport. A new member of this family was recently identified as TRAP1 (Tumor necrosis factor receptor-associated protein) or hsp75. TRAP1 is a mitochondrial protein that is an ATPase and ATP-binding protein, rendering it similar to hsp90. There is a high degree of homology between TRAP1 and hsp90 in 6 domains, however one major difference is that a highly charged domain present in hsp90 is absent in TRAP1. TRAP1 has been shown to interact with the intracellular domain of the type 1 receptor for tumor necrosis factor (TNFR-1IC) and to the retinoblastoma protein (Rb). Signaling through TNFR-1 induces antiviral responses, fibroblast proliferation, cytotoxicity, etc. TRAP1 binds TNFR-1IC outside of the death domain leading to disruption in the signaling by TNFR-1. Rb has been shown to play a pivotal role in cellular differentiation and progression through the cell cycle. TRAP1 associates with Rb via an LxCxE motif, which is common among proteins that interact with Rb through SV40 T-antigen binding domain. Thus, TRAP1 is a new member of the hsp90 family that interacts with Rb and TNFR-1IC.

Immunofluorescence, Western Blotting

Spécification

Spécification

Hsp75/TRAP1
Monoclonal
250μg/mL
TRAP1
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Western Blot
42
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Human Hsp75/TRAP1 aa. 253-464
50 μg
Cell Biology
Rat, Mouse, Human, Canine
IgG1
Vidéos
FDS
Documents

Documents

Certificats
Promotions

Promotions

For Research Use Only.