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Stat1 Mouse, Unlabeled, Clone: 1/STAT1, BD

Mouse Monoclonal Antibody

Marque:  BD Biosciences 610116

Informations supplémentaires : Poids : 0.01000kg

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Code produit. 15875269

  • 543.78€ / 1 kit
Expédition estimée: 21-02-2023
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Description

Description

Stat (Signal transducer and activators of transcription) proteins are critical mediators of the biologic activity of cytokines, including interleukins, interferons, erythropoietin, and growth factors. Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment/activation of Stat proteins by tyrosine phosphorylation. Active Stat proteins then move to the nucleus to promote transcription of cytokine-inducible genes. Seven Stat proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner. Stat1 and Stat2 are components of the ISGF3 (Interferon-Stimulated Gene Factor 3) complex, which is the primary transcription activator induced by the binding of the interferon to a specific cell-surface receptor. Stat1 has two alternatively spliced isoforms, 91kDa Stat1α and 84kDa Stat1β; Stat1α has 38 additional C-terminal amino acids. In response to the binding of IFNα, IFNγ, EGF, PDGF, or CSF-1 to their respective receptors, the Stat1 subunits become tyrosine-phosphorylated at Y701, and the complex is translocated to the nucleus. This results in the formation of an active complex that includes the DNA-binding p48 subunit. This complex is responsible for modulating the transcription of the interferon-stimulated genes (ISGs). Thus, phosphorylation of Y701 in Stat1 occurs in response to growth factors and cytokines, and is essential for normal transcriptional activity of the ISGF3 complex.

Host Species: Mouse
Clone: 1
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Stat1 aa. 1-194
Formula Weight [Chemical]: 91/84kDa

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Spécification

Spécification

Stat1
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Human Stat1 aa. 1-194
150 μg
Cell Biology
Rat, Mouse, Human, Frog, Chicken, Canine
IgG1
Western Blot
1/STAT1
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
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For Research Use Only.