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beta-Catenin Mouse anti-Human, Mouse, Porcine, Rat, Clone: 1B8A1, Proteintech
Mouse Monoclonal Antibody
Marque: Proteintech 66379-1-IG-20UL
Informations supplémentaires : Poids : 0.00010kg
Description
Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. AJs are necessary for the creation and maintece of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. Studies show that Beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases, phosphatases and Wnt/Wingless. The interplay between beta-catenin, cytoskeletal complexes and signaling pathways may regulate morphogenesis. Beta-catenin is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheats. A pathological role of beta-catenin has been identified in pilomatrixoma (PTR), medulloblastoma (MDB), colorectal cancer (CRC), ovarian cancer, and tumor development. In the nucleus, beta-catenin serves to co activate a family of Lef/Tcf transcription factors that stimulate transcription of target genes including those encoding cyclin D and c-myc that promote cell proliferation.Spécification
beta-Catenin | |
Monoclonal | |
1 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
P35222, Q02248, Q9WU82 | |
CTNNB1 | |
Peptide | |
20 μL | |
Primary | |
Mouse, Rat, Human, Porcine | |
Antibody | |
IgG1 |
Western Blot, Immunohistochemistry (Paraffin), Immunoprecipitation, Immunocytochemistry, Immunofluorescence | |
1B8A1 | |
Unconjugated | |
CTNNB1 | |
b cat, Beta catenin, beta-Catenin, Catenin beta 1, CTNNB, CTNNB1, PRO2286 | |
Mouse | |
Protein G | |
RUO | |
12387, 1499, 397657, 84353 | |
-20°C | |
Liquid |