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beta-Catenin Mouse anti-Human, Mouse, Porcine, Rat, Clone: 1B8A1, Proteintech

Mouse Monoclonal Antibody

140.00€ - 399.00€

Spécification

Antigène beta-Catenin
Clone 1B8A1
Concentration 1 mg/mL
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Monoclonal
Consulter d'autres spécifications

Produits 2
Code produit Marque Quantité Prix Quantité et disponibilité  
Code produit Marque Quantité Prix Quantité et disponibilité  
16838205
Afficher les documents Détails de la promotion
Proteintech
66379-1-IG-20UL
20 μL
140.00€
20µL
Voir les produits de remplacement
Économisez jusqu'à 
»
Expédition estimée: 15-04-2024
pour voir le stock disponible 
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16828205
Afficher les documents Détails de la promotion
Proteintech
66379-1-IG-150UL
150 μL
399.00€
150µL
Voir les produits de remplacement
Économisez jusqu'à 
»
Expédition estimée: 15-04-2024
pour voir le stock disponible 
Veuillez vous pour pouvoir commander cet article. Besoin d'un compte web? Créer le vôtre dès maintenant!
Description

Description

Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. AJs are necessary for the creation and maintece of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. Studies show that Beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases, phosphatases and Wnt/Wingless. The interplay between beta-catenin, cytoskeletal complexes and signaling pathways may regulate morphogenesis. Beta-catenin is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheats. A pathological role of beta-catenin has been identified in pilomatrixoma (PTR), medulloblastoma (MDB), colorectal cancer (CRC), ovarian cancer, and tumor development. In the nucleus, beta-catenin serves to co activate a family of Lef/Tcf transcription factors that stimulate transcription of target genes including those encoding cyclin D and c-myc that promote cell proliferation.
Spécification

Spécification

beta-Catenin
1 mg/mL
Monoclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
b cat, Beta catenin, beta-Catenin, Catenin beta 1, CTNNB, CTNNB1, PRO2286
CTNNB1
IgG1
Protein G
Antibody
1B8A1
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
Mouse
Human, Mouse, Porcine, Rat
P35222, Q02248, Q9WU82
12387, 1499, 397657, 84353
Peptide
Primary
-20°C
CTNNB1
Vidéos
FDS
Documents

Documents

Product Certifications