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FoxP3 Mouse, anti-Human, R718, Clone: 259D/C7, BD Horizon™

Mouse Monoclonal Antibody

Marque:  BD Biosciences 566936

Informations supplémentaires : Poids : 0.00020kg

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Code produit. 17257724

  • 341.00€ / 25 tests
Expédition estimée: 02-01-2023
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Description

Description

The 259D/C7 monoclonal antibody specifically recognizes human Forkhead box protein P3 (FoxP3) that is also known as Scurfin. FoxP3 is encoded by FOXP3 (Forkhead box P3), likewise known as IPEX (Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked) and JM2, that belongs to the forkhead/winged-helix family of transcriptional regulators. FoxP3 is expressed in CD4+ regulatory T cells (Treg) and represents a specific marker for these cells. Flow cytometric analyses have shown that FoxP3 is expressed by the majority of CD4+CD25+high T cells in peripheral blood while less than half of the CD4+CD25+intermediate cell population are FoxP3 positive. Approximately 5-10% of peripheral CD4+ cells are CD4+CD25+ T regulatory cells. T regulatory cells are thought to play a critical role in the regulation of T cell-mediated immunity and to protect against autoimmunity by suppressing the proliferation and cytokine production of other T cells. In support of this hypothesis, it has been found that Foxp3 is mutated in Scurfy (sf) mice that have defective T cell tolerance leading to an X-linked lymphoproliferative disease. The 259D/C7 antibody recognizes all currently-identified isoforms of human FoxP3 and is crossreactive with FoxP3 from Cynomolgus, Rhesus and Baboon primates.

Spécification

Spécification

FoxP3
Monoclonal
R718
25 Tests
Primary
Refrigerate Upon Arrival
Flow Cytometry
259D/C7
Mouse
RUO
Human
Liquid
Vidéos
FDS
Documents

Documents

Certificats
Promotions

Promotions