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OPA1 Mouse anti-Human, Mouse, Porcine, Rat, Clone: 1B2D8, Proteintech

Mouse Monoclonal Antibody

Marque:  Proteintech 66583-1-IG-20UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16828595

  • 121.38€ / 20µL
Expédition estimée: 28-09-2022
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Description

Description

OPA1 is a dynamin-related GTPase that is critical for the maintece of mitochondrial morphology and mtDNA. The most commonly associated phenotype with OPA1 mutations is heterozygous optic atrophy, a heterozygous domit trait that causes reduced visual clarity and sometimes blindness. The disease usually begins in childhood and increases in severity throughout the life of affected individuals. Usually, this phenotype is attributed to the degeneration of optic nerve fibers. Interestingly, the same type of nerve degeneration seems to be partially causative of certain schizophrenia characteristics. OPA1 dysfunction also seems to be implicated in this case; mitochondrial networks associated with critical nerves seem to link schizophrenia and OPA1. The dysfunction is associated with issues with apoptosis and normal cellular metabolic regulation, all regulated through OPA1.
Spécification

Spécification

OPA1
Monoclonal
1 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
O60313, P58281, Q2TA68
Opa1
OPA1 Fusion Protein Ag26868
20 μL
Primary
Rat, Human, Porcine, Mouse
Antibody
IgG2b
Western Blot
1B2D8
Unconjugated
OPA1
KIAA0567, largeG, MGM1, NTG, OPA1, Optic atrophy protein 1
Mouse
Protein A
RUO
100522705, 171116, 4976, 74143
-20°C
Liquid
Vidéos
FDS
Documents
Certificats
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