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Podoplanin Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 22099-1-AP-150UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16831645

  • 325.38€ / 150µL
Expédition estimée: 30-09-2022
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Description

Description

Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight. Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential. Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue. Further, it has also been determined that podoplanin expression is induced through Src activation of Cas and, recently, there are indications of podoplanin presence on Th17 cells. Initial studies below indicate the presence of podoplanin on a small but distinct population of CD4+ cells from human PBMC. Dysfunction of the podoplanin protein has been linked to diseases such as lymphangioma and subglottis neoplasm. Podoplanin has also been proposed as a marker for lung injury due to the physiological function of the protein.
Spécification

Spécification

Podoplanin
Polyclonal
Unconjugated
PDPN
AGGRUS, D2 40, D2 40,M2A, D240, Glycoprotein 36, GP36, Gp38, GP40, HT1A 1, M2A, OTS8, PA2.26, PA2.26 antigen, PDPN, Podoplanin, PSEC0025, T1 alpha, T1A, T1A 2
Rabbit
Antigen Affinity Chromatography
RUO
10630
-20°C
Liquid
Western Blot
0.35 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q86YL7
PDPN
Podoplanin Fusion Protein Ag17307
150 μL
Primary
Human
Antibody
IgG
Vidéos
FDS
Documents
Certificats
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