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TNNC1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marque: Proteintech 13504-1-AP-150UL
Informations supplémentaires : Poids : 0.00010kg
Description
Troponin, working in conjunction with tropomyosin, functions as a molecular switch, regulating muscle contraction in response to changes in the intracellular Ca2+ concentration. Troponin consists of three subunits: the Ca2+-binding subunit troponin C (TnC), the tropomyosin-binding subunit troponin T (TnT), and the inhibitory subunit troponin I (TnI). In response to beta-adrenergic stimulation of the heart, Ser23 and Ser24 of TnI (cardiac) are phosphorylated by PKA and PKC. This phosphorylation stimulates a conformational change of the regulatory domain of TnC, reduces the association between TnI and TnC, and decreases myofilament Ca2+ sensitivity by reducing the Ca2+ binding affinity of TnC (1-3).Spécification
TNNC1 | |
Polyclonal | |
Unconjugated | |
TNNC1 | |
CMD1Z, TN C, TNC, TNNC, TNNC1, troponin C type 1 (slow) | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
21924, 290561, 7134 | |
-20°C | |
Liquid |
Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
0.57 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
P19123, P63316 | |
Tnnc1 | |
TNNC1 Fusion Protein Ag4339 | |
150 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |