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TNNC1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 13504-1-AP-150UL

Informations supplémentaires : Poids : 0.00010kg

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Code produit. 16891744

  • 349.00€ / 150µL
Expédition estimée: 09-12-2022
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Description

Description

Troponin, working in conjunction with tropomyosin, functions as a molecular switch, regulating muscle contraction in response to changes in the intracellular Ca2+ concentration. Troponin consists of three subunits: the Ca2+-binding subunit troponin C (TnC), the tropomyosin-binding subunit troponin T (TnT), and the inhibitory subunit troponin I (TnI). In response to beta-adrenergic stimulation of the heart, Ser23 and Ser24 of TnI (cardiac) are phosphorylated by PKA and PKC. This phosphorylation stimulates a conformational change of the regulatory domain of TnC, reduces the association between TnI and TnC, and decreases myofilament Ca2+ sensitivity by reducing the Ca2+ binding affinity of TnC (1-3).
Spécification

Spécification

TNNC1
Polyclonal
Unconjugated
TNNC1
CMD1Z, TN C, TNC, TNNC, TNNC1, troponin C type 1 (slow)
Rabbit
Antigen Affinity Chromatography
RUO
21924, 290561, 7134
-20°C
Liquid
Western Blot, Immunoprecipitation, Immunohistochemistry (Paraffin), Immunofluorescence
0.57 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P19123, P63316
Tnnc1
TNNC1 Fusion Protein Ag4339
150 μL
Primary
Rat, Mouse, Human
Antibody
IgG
Vidéos
FDS
Documents
Certificats
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